High-quality instructional materials (HQIM) designed for next generation science can make a difference in the quality of equitable science teaching and learning throughout the educational system and for all learners (i.e., for all leaders, teachers, and students). So how can local leaders take a systems approach to the selection, broad and effective implementation, and sustained improvements offered by such materials? What are some practical ways to make this work in our community? Participants will consider these questions as they are introduced to systems thinking and the drivers that impact the successful implementation of high-quality instructional materials. Participants will also learn more about these system drivers through the stories of large and small districts who took on the challenge of implementing high-quality instructional materials at the middle school level. Participants will consider their own context and readiness for such an initiative.